Inendima yale miba inegama lomzimba
Ukuqonda izinto zeTranscription
Ukuze imizimba yethu ibe neentlobo ezahlukeneyo zeeseli, kufuneka kubekho indlela yokulawula i- geni yethu. Kwezinye iiseli, ezinye izakhi zegesi zivaliwe, ngelixa kwezinye iiseli zibhalwa kwaye ziguqulelwe kwiiprotheni.
Iimpawu zeTranscription zingenye yezixhobo eziqhelekileyo ezisetyenzisiweyo zethu kusetyenziswa ukulawula ukuthetha kwegenesis.
Inkcazo emfutshane
Iziganeko zeTranscription (TFs) ziyi-molecule ezibandakanyekayo ekulawuleni umqondiso wegazi. Ngokuqhelekileyo iiprotheni, nangona nazo zingaquka i- RNA emfutshane, engekho yekhowudi. I-TFs ibonakala isebenza kumaqela okanye kwiinkomfa , ukudala ukusebenzisana okuvakalayo okuvumela ukuba iinqununu zokulawula iirhafu zokubhalisa.
Ukuguqulwa kweGenesis Ukuphuma kunye no-On
Kubantu (kunye nezinye i-eukaryoti), iigleji zihlala zihlala kwindawo engagqibekanga , "ngoko i-TFs isebenza ngokuyinhloko ukuguqula igama" kwi . ". Kwiibhaktheriya, ngokuphindaphindiweyo kuyenzeka, kwaye izakhi zofuzo zibonakaliswa " ngokuzikhethela " de i-TF iguqula "." I-TF isebenza ngokuqaphela ukulandelelana kwee-nucleotide ezithile (i-motif) ngaphambi okanye emva kwe-gene kwi-chromosome (phezulu nangaphezulu).
IGenesis neEukaryoti
I-Eukaryot ihlala ibe nommandla okhuthaza umgangatho ophezulu ukusuka kwimida, okanye kwimimandla ephuculayo phezulu okanye ngaphantsi kwe-gene, ngeempawu ezithile ezithile ezibonakalayo kwiindidi ezahlukeneyo ze-TF.
I-TF zibopha, zitsho ezinye i-TF kwaye zenze i-complex edibanisa i-RNA polymerase, ngoku qalisa inkqubo yokubhala.
Kutheni kutheni izinto zeTranscription zibalulekile
Iingxelo zenguqulelo zinye yindlela enye iiseli zethu ezibonisa ukudibanisa ezahlukeneyo zegesi, okuvumela ukuhlukana kwiintlobo ezahlukeneyo zeeseli, izicubu kunye nezitho ezenza imizimba yethu.
Nangona kunjalo, le ndlela yokulawula ibaluleke kakhulu, ngokukodwa ekufumaneni iziphumo zeProjekthi ye-Human Genome ukuba sinezifo ezincinane kwi-genome yethu, okanye kuma-chromosomes ethu, kunokuba sicinga ngaphambili.
Oko kuthetha ukuthini iiseli ezahlukeneyo azange zivele kwiintetho ezahlukeneyo zeejethi, kodwa ziyakwazi ukuba nemilinganiselo ehlukeneyo yegama elikhethiweyo lamaqela afanayo.
I-Cascade Impact
I-TF iyakwazi kwakhona ukulawula intetho yesigidi ngokudala i-" cascade " impembelelo, apho ubukho bemali encinane yeprotheyini enye ibangela ukuveliswa kwemali emikhulu yesibini, okubangela ukuveliswa kwemali eninzi yesithathu, njalo njalo. Iinkqubo ezibangelwa yimiphumo ebalulekileyo eyenziwa yimali encinci yezinto zokuqala okanye ukuvuselela zizinto eziphambili zentuthuko ye-biotechnology yanamhlanje kwi- Smart Polymer yophando.
Ukubonakalisa iGene nokuLindela koBomi
Ukucwangcisa i-TF ukuguqula inkqubo yokuhlukanisa isisiseko yindlela yokufumana iiseli ezinamaqhina avela kumathambo omdala. Ukukwazi ukulawula ukubonakaliswa kwesigidi, kunye nolwazi olufunyenwe ekufundeni i-genome yabantu kunye ne-genomics kwezinye iindawo eziphilayo, kuye kwaholela kwingcamango yokuba sinokulondoloza ixesha lobomi bethu xa silawula kuphela iizakhi ezilawula ukuguga kwiiseli zethu.