Kukho ukungafani kunye nokufana phakathi kweSiRNA kunye ne-IRRNA
Yintoni i-irRNA vsMRNA?
Ngaphambi kokuba uqonde iindlela iindlela ze-irRNA kunye ne-miRNA ezifanayo kunye nendlela ezahlukileyo ngayo, kunceda ukwazi oko bakuyo. Zombini i-irRNA kunye ne-miRNA zixhobo zokusetyenziswa kweproteomics ezisetyenziselwa ukufundisisa imiba eyahlukileyo yemfuza. Iproteomics isifundo seeprotheni apho isalathisi esipheleleyo se-proteins ihlolwa ngokukhawuleza.
Uphuhliso lwezobuchwepheshe lwenze isifundo esinjalo senzeke.
Ngabe i-siRNA ne-miRNA efanayo okanye eyahlukileyo? I-jury isacacile kulo mbuzo, kuxhomekeke kubani owucelayo. Ezinye imithombo zivakalelwa kukuba i-siRNA kunye ne-miRNA zizinto ezifanayo, ngelixa ezinye zibonisa ukuba zizinto ezihlukeneyo ngokupheleleyo.
Ukungavumelani kuza ngeenxa yokuba ezi zombini zenziwe ngendlela efanayo. Zivela kwii-RNA zangaphambili. Zabo zombini ziqhutywe kwi-cytoplasm nge- enzyme ebizwa ngokuba yiDicer ngaphambi kokuba yingxenye yeprotein ene-RISC. Ama-enzyme angama-protein angaphucula izinga lokuphendula phakathi kwe-biololecules.
Kukho ukungafani okuKhanya phakathi kweBini
Inkqubo yokuphazamiseka kwe-RNA (RNAi) ingamodareyithwa ngu- siRNA okanye i-miRNA, kwaye kukho ukungafani okuphambene phakathi kwezi zibini. Njengoko kubonisiwe, zombini iqhutyelwa ngaphakathi kweseli nge-enzyme Dicer kwaye ifakwe kwi-RISC enzima.
i -RRNA ithathwa njenge-RNA ephindwe kabini ekhutshwe yileli. Ngamanye amagama, lingena kwiimvenge , njengee-virus. Iimvelaphi zivela xa iimfuzo zendalo zisebenzisa ii-bits ze-DNA ukuze zenze i-gene ivelise i-gene ( GMO ). I-DNA esetyenziswe kule nkqubo ibizwa ngokuba yivot.
Nangona i-siRNA icatshangelwa ukuba iyinto engaqhelekanga ye-RNA emibini, i-miRNA iyinto engatshatanga.
Ivela kwi-RNA engapheliyo ye-non -ododing, oku kuthetha ukuba yenziwe ngaphakathi kweseli. Le RNA ifunyenwe ngaphakathi kweemoloni ezinkulu zeRNA.
Eminye ukungafani kwezinye
Olunye umehluko phakathi kwe-siRNA kunye ne-miRNA kukuba i-siRNA ibopha ngokugqibeleleyo kwi-MRNA ekujoliswe kuyo kwizilwanyana. Umdlalo ogqwesileyo ukulandelelana. Ngokwahlukileyo, i-miRNA ingavimbela ukuguqulelwa kweendlela ezininzi zeMRNA ezahlukileyo ngenxa yokubambisana kwayo. Ukuguqulelwa kwenzeka emva kokuba i-RNA yomthunywa iguqulwe kwaye ibopha kwindawo ethile kwi-ribosome. Kwizityalo, i-miRNA ihlala ilandelelana ngokulandeleleneyo, ekhuthaza ukuhlenga kwe-mRNA ngokuchasene nokunyanzelwa kokuguqulelwa.
iRRNA kunye ne-miRNA banokudlala indima epigenetics ngokusebenzisa inkqubo ebizwa ngokuba yi-RNA-incuted transcriptional silence (RITS). I-Epigenetics yinto yokufunda ngolwazi olulungelelwanyo lwezofuzo apho i-nucleotide ilandelelwano lwe-DNA ayitshintshi kodwa ibonakaliswe njengempawu zamachiza. Ezi manqaku zongezwa kwi-DNA okanye i-chromatin proteins emva kokuphindaphinda. Ngokufanayo, zombini iithagethi ezibalulekileyo zokusetyenziswa kweyonyango ngenxa yeendima abazidlalayo kwi-gama yokulawula.